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February 2019

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'Egg yolk' treatment ends mum's miscarriage heartbreak

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'Egg yolk' treatment ends mum's miscarriage heartbreak

Post by AlleyRose on Sat Apr 26, 2014 10:12 am

After suffering six miscarriages in as many years, Lorraine Donakey had almost given up on her dreams of becoming a mother. But she has now given birth to a healthy baby girl thanks to a new treatment which involved a substance containing egg yolk being administered to her around the time of conception. 
The UK woman found out about the new treatment by chance after spending countless hours online looking for any information which might help her have a successful pregnancy.
"After my third miscarriage, I realised there was something more to it,'' 23-year-old Lorraine told UK newspaper Liverpool Echo.

Now a mum ... Lorraine Donakey. Photo: Star Now
"I was referred to the miscarriage clinic who treated me for a blood clotting disorder. I had to take heparin and aspirin. But on the fourth, fifth and sixth pregnancy it was still happening."
After experiencing her sixth miscarriage doctors told Lorraine there was nothing more they could do to help her and advised her to just keep trying.
"I just thought there's got to be another answer," she said. "I was searching online day after day and found this web page about natural killer (NK) cells and was convinced that was me."
Then a chance conversation with a friend who mentioned a fertility specialist offering a new treatment using intralipids led Ms Donakey to contact Dr Rafet Gazvani.
Dr Gazvani has been trialling the treatment which is based on a belief that some women's bodies contain too many NK immune cells. Although these cells play a vital part in a normal pregnancy, it is thought an abnormally high number of them in a women's uterus may result in an embryo being attacked as if it were a foreign body and lead to reccurrent miscarriage. 
Intralipids are a fat emulsion containing soya bean oil, egg yolk, glycerine and water. They are usually used to provide nourishment to people who are unable to absorb nutrient from food, but it is believed they also have an immuno-suppressant effect.
It is hoped the intralipids, which are administered to a woman via drip both before and after conception, will stabilise cell membranes and make it harder for the NK cells to attack the embryo.
Following the treatment Lorraine had a successful pregnancy and gave birth to daughter Lulu-Rose on January 17 this year.
"Having her in my arms is indescribable. When she was born I cried my eyes out. I’m so glad she’s here," Lorraine told the newspaper.
"Having six miscarriages takes its toll. I would look around and see people pushing prams, my friends had babies. It was heartbreaking to think that would never be me.  When I fell pregnant with Lulu-Rose there was the constant worry that I might lose her. Now that I have her I want other women to know about this and maybe it could work for them."
Medical Director of Australian fertility specialists Genea Doctor Mark Bowman said the use of intralipids is an accepted treatment but not yet recognised as established clinical practice.
He says the treatment is currently being trialled by Genea but, if proven to be successful, is only likely to benefit a "small subset of women".
While Dr Bowman has seen some successful pregnancies after the use of intralipids, he says it is too early to know for certain that the treatment was the reason for the success.
"I have to say, I wouldn't be willing to stand up and scream about its success from a billboard,'' he said. "We still don't know whether (the pregnancies are) because of coincidence or benefit."
Dr Bowman stressed that women who suffer recurrent miscarriage needed to seek medical advice in order to have a series of examinations which might help determine a reason behind the failed pregnancies.

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